CALGARY: Scientists see Norwalk virus’ Achilles heel - (Canadian Light Source, Inc.)
March 19, 2008 – 6:03 pmhttp://www.eurekalert.org/pub_releases/2008-03/clsi-ssn031808.php
Using the Canadian Light Source synchrotron, an international team led by University of Calgary researcher Ken Ng has determined the detailed structure of the enzyme the Norwalk virus uses to make copies of its genetic code in order to replicate itself. The information is crucial to developing drugs that could be used to treat outbreaks of Norwalk and other related viruses.
The Norwalk virus uses the enzyme, RNA polymerase, to make new strands of RNA using an existing RNA strand as a template. The copying, which occurs within an area of the enzyme called an active site, can be blockedor inhibited–with a drug molecule shaped to fit the site, like a key in a key hole.
These are the first structures showing the enzyme doing its job interacting with RNA, says Professor Ng. These structures provide ideas of how we could develop new antiviral drugs that block the enzymes activity.
The group includes […]
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http://www.extension.iastate.edu/foodsafety/news/fsnews.cfm?newsid=24918
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