IOWA: Protein found to promote antibiotic resistance in a common food-borne pathogen - (Iowa State University)
June 5, 2008 – 5:23 pmResearchers from Iowa State University have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study, published June 6th in the open-access journal PLoS Pathogens, explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter, a bacterial pathogen commonly associated with food poisoning in humans.
Development of antibiotic resistance in Campylobacter, especially to fluoroquinolone (a broad-spectrum antimicrobial), compromises clinical therapy and poses a public health threat. Previous studies have revealed that Campylobacter is highly mutable to antibiotic treatment and the number of fluoroquinolone-resistant Campylobacter is greatly increased in many regions of the world. But it has not been clear why Campylobacter is able to mutate at such a high frequency.
Using various molecular tools, the research team from the College of Veterinary Medicine, led by Dr. Qijing Zhang, has found that Campylobacter […]
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